Box sets are not so different from either 1-4 or "Horns". I like the action Coaching Toolbox shares to move the defense.
The first action changes the alignment and spacing and yields a possible lob for a layup. If it's not there, 1 can go through to the corner with a high ball screen (2 and 4)...
3 can also use the baseline "Flex" action with 2 reversing the ball to 4 and setting a downscreen for 5 to complete the Flex with 5 getting an elbow jump shot. If you want to "bury" the 1 (strong side corner cut), 3 space up and you have the whole left side for the screen and roll.